School of Biochemistry
£32,548 - £36,613 per annum (Grade I) £36,613 - £41,212 per annum (Grade J)
Based within the School of Biochemistry, you will join the research group of Dr Jan Frayne to work on an MRC funded project to study how mutation in the erythroid specific transcription factor KLF1 causes severe disease in humans. The project will generate the first model cellular system of human red blood cell disease utilising our recently developed novel erythroid cell line, which will be used to determine the underlying molecular basis of the disease.
Tasks will include genome editing using CRISPR-Cas9, analysis of protein expression and cutting edge genome analysis techniques, the latter in collaboration with the Weatherall Institute of Molecular Medicine (WIMM), Oxford University.
You will have experience of cell culture, molecular biology skills, experience of lab based research in Biochemistry or Biosciences and capacity to plan experiments and interpret results. Applicants should also have a PhD (or equivalent) in Biochemistry, Cell Biology or a related discipline.
There are two research positions funded by this project, one research associate has already been appointed. The various techniques (job tasks) required will therefore be shared dependent on experience and interests of the appointed researchers.
THE POSITION IS OPEN TO PREVIOUS APPLICANTS. SKILLS AND EXPERIENCE REQUIREMENTS HAVE BEEN REVISED.
For informal enquiries, please contact Dr Jan Frayne, Jan.Frayne@Bristol.ac.uk, Tel: 0117 3312127.
Interviews are expected to take place shortly after closing.
The University is committed to creating and sustaining a fully inclusive culture. We welcome applicants from all backgrounds and communities
The closing date for applications is 23.59 on 10th June 2018
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