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Postdoctoral Research Associate - Vascular Biology

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King’s College London


The salary will be paid at Grade 6, £33,518 - £37,706 per annum, plus £2,923 per annum London Allowance.
This post will be a Fixed Term Contract for 3 years (36 months)
This is a Full-time – 100% full time equivalent

Applications are invited for a 3 year postdoctoral research associate post in the group of Dr Sarah Chapple in the Vascular Biology Section (School of Cardiovascular Medicine & Sciences) and with Prof Giovanni Mann (School of Cardiovascular Medicine & Sciences) and Dr Paul Taylor (School of Life Course Sciences). The post is funded by the BHF and builds on our previous findings demonstrating that Nrf2 antioxidant defences are compromised following adverse pregnancy. It is well established that early life nutrition (under or over nutrition) can predispose offspring towards the development of cardiometabolic disease in later life and that early on, markers of vascular damage or dysfunction are observed.

This project will help us understand the role that antioxidant defences may play in this process. Nrf2 is a master regulator of antioxidant/phase II defence enzymes and is also known to repress pro-inflammatory pathways. Using a well validated model of murine obese pregnancy, this project will investigate whether restoration of Nrf2 defences during pregnancy prevents the long-term development of cardiometabolic disease in offspring. Moreover, the chosen candidate will employ a range of ex vivo and in vitro techniques to explore the underlying signalling mechanisms and consequences for Nrf2 induction in mother and offspring.

Prior experience working with animals, including in vivo and ex vivo assessment of cardiovascular function (e.g telemetry, myography) as well as previous use of molecular biology approaches and primary cell culture would be advantageous.

Candidates should have a background in developmental and/or cardiovascular physiology with excellent oral and written communication skills. In addition, you should be able to demonstrate a record of peer reviewed scientific publications, be able to prioritize competing tasks/workload and engage effectively with an interdisciplinary team here at King’s as well as liaise effectively with our internationally renowned collaborators.

The selection process will include a presentation and panel interview.
Interviews are scheduled to be held the week commencing 5 March 2018.

For an informal discussion to find out more about the role please contact Dr Sarah Chapple Email: Tel: +44(0)207 848 4830.

To apply for this role, please go to and register to download and submit the specified application form.

The deadline for applications is midnight on 25 February 2018.

Status: Research Scientist
Location: London, UNITED KINGDOM
Advert Published: 29 Jan 2018
Expiry date: 25 Feb 2018
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